Epidemiology, Causes and Outcome of Obstetric Acute Kidney Injury

Acute kidney injury (AKI) is a clinical syndrome denoted by an abrupt decline in glomerular filtration rate (GFR) sufficient to decrease the elimination of nitrogenous waste products (urea and creatinine) and other uremic toxins (Jefferson et al, 2010). AKI is a not very common yet serious complication occurring in pregnancy. The incidence and the mortality rates associated with obstetric acute kidney injury (also known as pregnancy related acute renal failure; PRARF) have decreased over the last few decades especially in developed countries (Prakash et al, 2007; Stratta et al, 1996). There are several factors which lead to this improvement and will be discussed later in the chapter. Since the term AKI is now widely used in place of acute renal failure (Ricci et al, 2011); for the ease of description we have used obstetric AKI in place of PRARF in this chapter.